UGT1A4 UM *1a/*3b [Increased activity] Ultrarapid metabolizer: Risk of decreased serum levels. I've never had a histamine level drawn, that I know of (possibly done by allergist). May not get enough medication at normal doses. Specifically UGT1A4 Was going over some old results and looking into things and I am an Ultrarapid Metabolizer for UGT1A4, which when I look up mentions rapid clearance of hormones, and specifically mentioned testosterone. Those who drank one to three cups of coffee daily had a significantly reduced risk of heart attacks – suggesting that for them coffee was protective. My folate level has always been above register (> 25.2 ng/ml). Possible adverse events associated with increased active metabolites A dose adjustment or alternate therapy may be considered U Be advised that there may be altered exposure to medications metabolized by UGT1A4 ABCB1 (rs2032583) A/G [Increased absorption/ The locus is defined by 13 first exons, which are alternatively spliced to 3 other common exons and 2 alternative terminal exons 5. (UGT1A4*3) increased glucuronidation’’ from GP: A male with chronic ischaemic pain in legs; no pain relief despite very high doses of codeine – ultrarapid metabolism? CYP2D6*4/*4, poor metaboliser, no bioactivation of codeine. UGT1A4 isoform is part of the UGT1A complex locus which displays alternative use of promoters, first exons and terminal exons. By using the AmpliChip CYP450 Test, out of 182 subjects, we identified 8 poor metabolizer (PM), 17 intermediate metabolizer (IM), 151 extensive metabolizer (EM) and 3 ultrarapid metabolizer (UM). Our findings therefore indicate that UGT1A4‐mediated metabolism is not a major contributor to interpatient variability in olanzapine levels. Visit our website for text version of this Definition and app download. However, with respect to other drugs for which UGT1A4 has a dominant role in clearance, increased glucuronidation encoded by UGT1A4*3 might impact the risk for subtherapeutic drug exposure. Ultrarapid Metabolizer Breaks down medications rapidly. Poor Metabolizer Breaks down medications very slowly. CaferMed LLC, 2020. from psychiatrist: A woman with pronounced adverse effects Labs this year that may be of interest: (Genesight, others) I was found to be homozygous for 677T, CYP2C9 Poor Metabolizer, UGT1A4 Ultrarapid Metabolizer, COMT MET/MET, ADRA2A C/C. 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